About

R2R Imprinted Microfluidics cover the whole development chain for microfluidic based lab-on-chip devices - Simulation & design: Fluid Dynamics & microfluidic design - Material selection & development: imprint resin & foil substrate - Microfluidic fabrication: stamp fabrication – UV-imprinting - Surface bio-functionalization: micro array spotting, ink jet printing, plasma activation - Lamination & backend: UV-lamination & laser cutting - Characterization: optical inspection, luminescence and electro-chemical read-out, surface characterization

Description

R2R microfluidics is made up of six modules, which can be accessed either individually or as a complete process flow to develop and evaluate microfluidic based lab-on-chip devices. These can be used for assay and drug development, point of care consumables, blood sampling or nanoparticle fabrication tools. Our modules cover the whole value chain, starting from simulation and design to characterization and validation of the chips.

We plan the fabrication process together with the user to achieve the desired functionalities and:

– discuss the target specifications and functionalities of the microfluidic based lab on chip system and perform fluid dynamic simulations (Module Simulation & Design)

– make the layout of the microfluidic channel or design the full lab on chip (Module Simulation & Design)

– select an adequate polymer substrate (refractive index, autofluorescence, recycled material) (Module Material), adapt or develop imprinting resins by considering user requirements (surface energy, biocompatibility, cell cytotoxicity, autofluorescence, refractive index, adhesion to substrate). We already have a wide range of imprinting resins in our NILcure family (Module Material)

fabricate the microfluidic channels, starting from mastering processes (photolithography, laser lithography), working stamp fabrication (galvanisation) and (roll-to-roll) UV imprinting (Module Microfluidic fabrication) 

perform the necessary surface treatment (plasma or Corona activation) and bio-functionalization (deposition of probe molecules via (roll-to-roll) microarray spotting, inkjet printing or aersosoljet printing (Module Surface bio-functionalization)

– characterize the properties of imprinted layers by SEM, AFM, surface profiler, tensile tester, contact angle measurements (Module Characterization)

– assemble the (functionalized) microfluidic layer with a cover foil via (roll-to-roll) UV lamination, or application of a screen-printed glue (Module Lamination & Backend)

use laser cutting for chip singulation and inlet and venting hole definition (Module Lamination & Backend) 

– test the functionality of the assembled microfluidic chip with optical inspection, filling tests, luminescence or electrochemical readout tests (Module Characterization)

Technical specifications:

Simulation & Design

AutoCad, Comsol

 

Microfluidic fabrication

Mastering with Photolithography

Galvanization tool

R2R UV-Imprinting Pilot line

 

Surface Biofunctionalization

Scienion Microarray spotter

PIXDRO Inkjet  with post processing

Aerosol Jet Printer

Plasma activation

 

Lamination

R2R UV imprinting pilot line

Screen printer

 

Backend

Trotec Laser cutter

Femtosecond Laser

 

Characterization:

Contact angle measurements

Tensile tester

Laser scanning microscope

Related technology:


 

Case study:

At JOANNEUM RESEARCH, we specialize in roll-to-roll replication by UV-imprinting, transferring fast and cost effective your designs of nano- and microstructures. We provide precise and efficient imprinting solutions onto any kind of transparent polymer film and a widely tuneable UV curable resin. Our comprehensive services start with simulation and design of your microfluidic application, covers mastering and polymer tool fabrication, material adjustment (e.g, surface energy, functional anchor groups, refractive indices, adhesion properties) and replication of structures on large (polymer foil) areas:

Replication Test Package:

Discover the compatibility of your designs with our platform. This package evaluates design suitability, identifies upscaling opportunities, and provides you with replicated samples for on-site inspection.

Demonstration Projects:

Customized research projects that go beyond replication. JOANNEUM RESEARCH offers tailored investigations, encompassing mastering services, stamp production, replication testing, using a broad parameter sweep to assess compatibility, and a comprehensive analysis of the study results.

Upscaling Capabilities:

Unlock the potential for increased production. JOANNEUM gives you the ability to scale up your microfluidic device manufacturing, ensuring efficient and cost-effective solutions.

Experience the Efficiency of Roll-to-roll Replication

JOANNEUM is your trusted partner for replicating microfluidic designs into UV curable resins on polymer films. Contact us today to explore how we can efficiently bring your microfluidic projects to life.

The roll-to-roll platform

Our high throughput R2R pilot line allows fast replication of customized patterns via UV imprinting.  Hereby, a UV curable polymer resin is applied on a polymer carrier substrate before being in contact with a structured roller. Curing of the resin is done via UV light induced polymerization. 

Our technology has significant advantages in comparison competing R2R technologies:

  1. High production speeds m2/min
  2. Wide tuneability of UV curable resin, properties adjustable
  3. Known surface properties and chemistry
  4. Imprint on a web width up to 300 mm 
  5. Adjustable film thickness up to 300µm. 
  6. Simultaneous replication of geometries from nanometers to micrometer sizes
  7. Low and high aspect ratio structures (up to AR 1:3)
  8. Closing of the produced chips by R2R UV lamination, ensuring the same resin properties on all sides of the chip

Access Provider / Facilities

JOANNEUM RESEARCH