BioProbe is a collaborative initiative by the biophotonics team at Tyndall, focusing on the design and integration of miniature biophotonics probes and sensors for prototyping. This project aims to create advanced probes specifically tailored for various biophotonics applications. The design process considers critical aspects to ensure high performance, miniaturisation and precision.


Advancements in biophotonics have opened new frontiers in medical diagnostics, environmental monitoring, and other critical fields. At the forefront of this innovation is the BioProbe initiative, a initiative focuses on the meticulous design and integration of miniature probes and sensors for prototyping, addressing the unique demands of biophotonics applications.

Our team at Tyndall has experience in the design and development of miniature probes for wide range biophotonics technologies including time domain diffuse reflectance spectroscopy, fluorescence lifetime imaging, fluorescence and Raman probes. By leveraging their expertise, the team at Tyndall has developed number of demonstrators showcasing our highly specialized probes technology, that enhance performance at reduced probe footprint, driving forward the capabilities of biophotonic technology.

Technical specifications:

Probes technologies: Fluorescence, FLIM, Diffuse reflectance, time domain diffuse reflectance probes, Raman probes.

Geometry: Contact and non-contact geometry

Components for integration: prisms, lenses, filters, 3D printed mounts, fiber and fiber optics, mirrors, microcameras.

Case study:

Case study 1: we designed and developed chip on tip Fluorescence lifetime endoscope and packed in our lab. This demonstrates our capabilities to integrate time resolved SPAD arrays, lenses, filters, casing into a FLIM endoscope.

Reference: Dario Angelone, Sanathana Konugolu Venkata Sekar, Walter Messina, Andrew Matheson, Ahmet T. Erdogan, Robert K Henderson, Ray Burke, Stefan Andersson-Engels, “Time resolved SPAD micro-camera probe for wide-field FLIm in microendoscopy,” Proc. SPIE 12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI, 1236807 (6 March 2023); https://doi.org/10.1117/12.2648340

Case study 2: We designed and developed hybrid time of flight microcamera system for deep tissue sensing applications. The probe offers high spatial resolution (specular imaging) using microcamera and depth sensitivity using pToF spectroscopy integrated in the same probe.

Reference: Hasti Yavari, Suraj Kumar Kothuri, Pranav Lanka, Stefan Andersson-Engels, Sanathana Konugolu Venkata Sekar “Endoscopic Photon Time-of-Flight System for Guidance of Complete Response” Optica Biophotonics Congress: Biomedical Optics 2024, TM3B.3.

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